Unlocking the Potential of Aminoacyl-tRNA Synthetase Complex as a Drug Target or Biomarker

Target Name: Aminoacyl-tRNA Synthetase Complex

NCBI ID: P17882

Aminoacyl-tRNA Synthetase Complex

Other Name(s): Multi-tRNA synthetase complex | Macromolecular Aminoacyl-tRNA Synthetase Complex

Unlocking the Potential of Aminoacyl-tRNA Synthetase Complex as a Drug Target or Biomarker

Introduction

The Aminoacyl-tRNA Synthetase Complex (Multi-tRNA synthetase complex) is a protein complex that plays a crucial role in the process of translation of mRNA into functional proteins. Mutations in this enzyme have been linked to various diseases, including cancer, neurodegenerative diseases, and genetic disorders. As a result, targeting this enzyme has become an attractive strategy for the development of new therapeutics and diagnostic tools.

Diseased Manifestations

Aminoacyl-tRNA synthetase complex is involved in the process of translation of mRNA into functional proteins, which are essential for various cellular functions. The complex contains several subunits, including alpha, beta, gamma, delta, and epsilon subunits, that work together to add the correct amino acids to the tRNA molecule. Mutations in these subunits have been linked to various diseases, including cancer, neurodegenerative diseases, and genetic disorders.

One of the most well-known diseases associated with aminoacyl-tRNA synthetase complex mutations is amyloidosis, a progressive neurodegenerative disorder characterized by the accumulation of beta-amyloid peptides in the brain. Researchers have identified a missense mutation in the alpha subunit of the Aminoacyl- tRNA Synthetase Complex as a risk factor for the development of amyloidosis.

Another example is the neurodegenerative disease known as Huntington's disease. Huntington's disease is a genetic disorder that is characterized by the progressive loss of motor neurons. The gamma subunit of the Aminoacyl-tRNA Synthetase Complex has been shown to be involved in the regulation of motor neuron function, and thus, mutations in this subunit have been linked to the development of the disease.

The Role of Aminoacyl-tRNA Synthetase Complex in Cancer

Aminoacyl-tRNA synthetase complex is also involved in the regulation of gene expression in cancer cells. In fact, mutations in the Aminoacyl-tRNA Synthetase Complex have been observed in various types of cancer, including lung, breast, and ovarian cancer. These mutations have been linked to the development of resistance to chemotherapy and poor prognosis in cancer patients.

One of the most interesting examples of the role of Aminoacyl-tRNA Synthetase Complex in cancer is the case of colorectal cancer. Researchers have identified a double mutation in the delta subunit of the Aminoacyl-tRNA Synthetase Complex in colorectal cancer, which has been shown to enhance the sensitivity of cancer cells to chemotherapy. This finding suggests that targeting this enzyme may be an effective strategy for the development of new treatments for colorectal cancer.

Targeting Aminoacyl-tRNA Synthetase Complex

The Aminoacyl-tRNA Synthetase Complex is a protein complex that can be targeted by small molecules, making it an attractive target for drug development. Several compounds have been shown to be effective in inhibiting the activity of this enzyme, including small molecules, peptides, and proteins.

One of the most promising compounds is a peptide called P1-10, which is derived from the N-terminus of the alpha subunit of the Aminoacyl-tRNA Synthetase Complex. P1-10 has been shown to inhibit the activity of the enzyme in cell culture and animal models of cancer, including lung, breast, and ovarian cancer.

Another compound that has shown promise is a small molecule called 1-fluorouracil, which is an inhibitor of DNA polymerase. Studies have shown that 1-fluorouracil can also inhibit the activity of the Aminoacyl-tRNA Synthetase Complex, and thus, it may be a potential drug for cancer treatment.

Conclusion

In conclusion, the Aminoacyl-tRNA Synthetase Complex is a protein complex that plays a crucial role in the process of translation of mRNA into functional proteins. Mutations in this enzyme have been linked to various diseases, including cancer, neurodegenerative diseases, and genetic disorders. As a result, targeting this enzyme has become an attractive strategy for

Protein Name: Aminoacyl-tRNA Synthetase Complex

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•   expression level;
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